Research on Plants for the Understanding of Diseases of Nuclear and Mitochondrial Origin

Table 1

Overview of studies linking DNA repair pathways and disorders in humans and plants.

Genetic deficiency^a	DNA repair pathway defect^b	Human disease^c	Reference	Plant disorder^d	Reference
MSH2; MSH6; MLH1; PMS2(1)	MMR	HNPCC	[23]	MSI Homeologous recombination	[33, 34, 37–41]
XPA; XPB; XPC; XPD; XPE; XPF; XPG	NER	XP	[48]	Hypersensitivity to UV	[90, 93–95, 97, 98]
ATM	DSB	AT	[101]	Hypersensitivity to γ radiation,; X-ray, radiomimetic agents	[115, 117, 118]

^aMSH: MutS homolog; MLH: MutL homolog; PMS: postmeiotic segregation; XPA-XPG: xeroderma pigmentosum A-G; ATM: ataxia telangiectasia mutated.
^bMMR: mismatch repair; NER: nucleotide excision repair; DSB: double-strand break.
^cHNPCC: hereditary nonpolyposis colon cancer; XP: xeroderma pigmentosum; AT: ataxia telangiectasia.
^dMSI: microsatellite instability.