Identification of HLA-A24-Restricted Novel T Cell Epitope Peptides Derived from P-Cadherin and Kinesin Family Member 20A
Table 1
Candidates of epitope peptide derived from CDH3 and KIF20A.
CDH3
KIF20A
Start position
Amino acid sequence (mer)
Binding score
CTL induction
Start position
Amino acid sequence (mer)
Binding score
CTL induction
513
IYEVMVLAM (9)
37.5
–
308
IYNELLYDL (9)
432
–
667
LFLLLVLLL (9)
36
–
621
MYEEKLNIL (9)
432
–
30
VFREAEVTL (9)
24
+
67
VYLRVRPLL (9)
420
–
406
LYVEVTNEA (9)
16.6
+
499
KFSAIASQL (9)
56
–
332
KYEAHVPEN (9)
16.5
+
304
SFFEIYNEL (9)
44.352
–
180
KYELFGHAV (9)
15
+
187
IFNSLQGQL (9)
36
–
85
RSLKERNPL (9)
14.4
–
305
FFEIYNELL (9)
30
+
5
RGPLASLLL (9)
12
+
23
MFESTAADL (9)
30
–
652
KGGFILPVL (9)
11.2
–
256
SFDSGIAGL (9)
20
–
248
TYNGVVAYS (9)
10.5
+
298
RFSIWISFF (9)
20
–
65
LFSTDNDDF (9)
10
–
383
IFSIRILHL (9)
20
+
807
DYLNEWGSRF (10)
150
+
647
KIEELEALL (9)
17.28
–
248
TYNGVVAYSI (10)
105
+
625
KLNILKESL (9)
14.4
–
667
LFLLLVLLLL (10)
42
–
695
KLQQCKAEL (9)
13.2
–
397
DFEAKNQHTL (10)
30
+
726
FTIDVDKKL (9)
11.088
–
332
KYEAHVPENA (10)
21
+
688
QLQEVKAKL (9)
11.088
–
180
KYELFGHAVS (10)
15
+
308
IYNELLYDLL (10)
432
–
510
RNNIYEVMVL (10)
12
+
182
RSLALIFNSL (10)
24.192
+
5
RGPLASLLLL (10)
12
–
304
SFFEIYNELL (10)
24
+
477
RILRDPAGWL (10)
12
+
742
RLLRTELQKL (10)
15.84
–
556
CNQSPVRQVL (10)
10.1
+
739
KNIRLLRTEL (10)
15.84
–
218
RQEEMKKLSL (10)
14.4
+
70
RVRPLLPSEL (10)
12.672
–
871
RILRSRRSPL (10)
12
–
89
RIENVETLVL (10)
12
+
364
KNQSFASTHL (10)
12
–
66
KVYLRVRPLL (10)
11.2
+
60
DSMEKVKVYL (10)
10.08
–
Start position indicated the number of amino acids from the N terminal of CDH3 and KIF20A. Binding score was obtained using BIMAS program. CTL induction was indicated as positive (+) or negative (–). Similar results were obtained 3–7 independent experiments using PBMC of 3–7 healthy volunteers.
