The Effect of Glycyrrhetinic Acid on Pharmacokinetics of Cortisone and Its Metabolite Cortisol in Rats

Table 2

The main pharmacokinetic parameters of cortisol in two groups 𝑛=6.

Pharmacokinetic parameters	E	E + GA
𝑡1/2𝛽/min	60.859 ± 4.065	62.557 ± 5.415
CL/F/L·min^−1·kg^−1	0.343 ± 0.012	0.284 ± 0.011**
AUC(0-𝑡)/mg·min·L^−1	53.054 ± 2.102	64.416 ± 2.776**
AUC(0-∞)/mg·min·L^−1	58.411 ± 2.038	70.576 ± 2.656**
𝐶max/mg·L^−1	0.627 ± 0.04	0.815 ± 0.033**

* 𝑃<0.05; **𝑃<0.01 in comparison to E.