The Immunogenicity of the Tumor-Associated Antigen <b><i>α</i></b>-Fetoprotein Is Enhanced by a Fusion with a Transmembrane Domain

<table>Induction of AFP-specific antibodies after vaccination with MVA-T mAFP. (a) Schematic of the experimental design. (b) ELISA analysis of sera from mice vaccinated with MVA-null, MVA-s mAFP, MVA-I mAFP, or MVA-T mAFP. Mean absorbances are determined at dilutions 1 : 50, 1 : 250, and 1 : 1000. (c) Time course of AFP-specific antibodies titre in sera from mice (<svg height="10.9125" id="M3" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 35.099998 10.9125" width="35.099998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.9125)">
<g transform="translate(72,-63.27)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 12.50px; " x="9.6773224" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="21.71771" y="0">3</tspan>
</text>
</g>
</g>
</svg>) vaccinated with MVA-T mAFP. The absorbance is determined for a 1 : 50 dilution.</table>

BioMed Research International

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Figure 4

Figure 4: The Immunogenicity of the Tumor-Associated Antigen <b><i>α</i></b>-Fetoprotein Is Enhanced by a Fusion with a Transmembrane Domain 

BioMed Research International

The Immunogenicity of the Tumor-Associated Antigen α-Fetoprotein Is Enhanced by a Fusion with a Transmembrane Domain

Figure 4