Persistent Dystrophin Protein Restoration 90 Days after a Course of Intraperitoneally Administered Naked 2′OMePS AON and ZM2 NP-AON Complexes in mdx Mice

<table>RT real time PCR exon-skipping quantification. Histograms show the percentages of exon–23-skipped transcript, calibrated on exons 8 and 25 (ΔΔCt method) and calculated in treated (ZM2-AON and naked AON) with respect to untreated mdx mice. The in-frame skipped product was detected in all skeletal muscles and the heart at percentages ranging from 6.3 to 9.5% in ZM2–AON-treated mice (black bars) and from 2.6 to 6.5% after treatment with naked AON (grey bars). Asterisks (*) indicate statistical significance at  <svg height="11.25" id="M13" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 63.962502 11.25" width="63.962502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
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<tspan style="font-size: 12.50px; " x="10.890113" y="0">&lt;</tspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="29.182001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="38.559254" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="44.810753" y="0">5</tspan>
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</svg>. Error bars represent mean ± SD.</table>

BioMed Research International

fig1

Figure 1

Figure 1: Persistent Dystrophin Protein Restoration 90 Days after a Course of Intraperitoneally Administered Naked 2′OMePS AON and ZM2 NP-AON Complexes in mdx Mice 

Figure 1 | Persistent Dystrophin Protein Restoration 90 Days after a Course of Intraperitoneally Administered Naked 2′OMePS AON and ZM2 NP-AON Complexes in mdx Mice 