The Inhibitory Effect of Prunella vulgaris L. on Aldose Reductase and Protein Glycation

Table 2

Inhibitory effects of the compounds isolated from the P. vulgaris L. on rat lens aldose reductase (rAR) and human recombinant aldose reductase (rhAR).

Compounds	rAR	rhAR
	IC50 (𝜇M)^a
Quercetin^b	5.66 ± 1.05	19.23 ± 0.74
1	—	—
2	—	—
3	8.35 ± 0.51	—
4	2.77 ± 0.48	18.62 ± 0.40
5	3.20 ± 0.55	12.58 ± 0.32
6	—	—

^aInhibition rates were calculated as percentages with respect to the control value. The IC₅₀ values of each sample were estimated from the least-squares regression line of the logarithmic concentration plotted against inhibitory activity. ^bQuercetin was used as positive control. Inhibitory effect was expressed as mean ± SD of triplicate experiments.