Effects of Ginsenoside 𝐑𝐛_𝟏 on Skin Changes

Table 1

Effects of various ginseng saponins on angiogenesis.

Effects of ginsenoside Rb2 (100 μg/mouse, iv) on tumor-induced angiogenesis in B16-BL6 melanoma-inoculated mice (in vivo); Ginsenoside Rb2 showed antiangiogenesis [25].
Effects of ginsenoside Rb2 (100 μg/mouse, iv and 300 μg/mouse, po), 20(R)Rg3 (100 μg/mouse, iv and 300 μg/mouse, po), and 20(S)Rg3 (100 μg/mouse, iv and 300 μg/mouse, po) on tumor-induced angiogenesis in B16-BL6 melanoma-inoculated mice (in vivo).; Ginsenoside Rb2, 20(R)Rg3 and 20(S)Rg3, showed antiangiogenesis [40].
Effects of the total saponin fraction (10–100 μg/mL) on tube formation by HUVECs (in vitro).; The total saponin fraction enhanced angiogenesis [22].
Effects of ginsenoside Rg1 (10 μM) and Rb1 (10 μM) on angiogenesis in scaffold implants in mice (in vivo).; Effects of Rg1 (125 nM) and Rb1 (125 nM) on chemoinvasion in HUVEC (in vitro).; Ginsenoside Rg1 enhanced angiogenesis, and ginsenoside Rb1 showed antiangiogenesis in the earliest stage [23].
Effects of ginsenoside Re (10–100 μg/mL) on angiogenesis in HUVECs (in vitro).; Effects of Re (70 μg/extracellular matrix) on angiogenesis in extracellular matrix-implanted rats (in vivo).; Ginsenoside Re showed angiogenesis [41].
Effects of ginsenoside Rg1 (150–600 nM) on angiogenesis in HUVECs (in vitro).; Effects of Rg1 (600 nM/Matrigel) on angiogenesis in Matrigel-implanted mice (in vivo).; Ginsenoside Rg1 promoted angiogenesis [42].
Effects of 20(R)-ginsenoside Rg3(1-1000 nM) on angiogenesis in HUVECs (in vivo).; 20(R)-ginsenoside Rg3 showed antiangiogenesis [43].
Effects of Ginsenoside Rg1 (150 nM) on angiogenesis in HUVECs (in vitro).; Ginsenoside Rg1 promoted angiogenesis [44].
Effects of ginsenoside Rg1 (30 μg/mL) and Re (30 μg/mL) on angiogenesis in HUVECs (in vitro).; Effects of Rg1 (50 μg/mL) and Re (50 μg/mL) on angiogenesis in Matrigel-implated mice (in vivo).; Ginsenoside Rg1 and Re promoted angiogenesis [45].
Effects of ginsenoside Rg3 (3 mg/kg, ip) on growth and angiogenesis of ovarian cancer (in vivo).; Ginsenoside Rg3 showed antiangiogenesis [46].
Effects of ginsenoside Rb1 (250 nM) on angiogenesis in HUVECs (in vitro).; Ginsenoside Rb1 showed antiangiogenesis [47].
Effects of ginsenoside Rg1 (500 μg/Matrigel) on angiogenesis in Matrigel-implanted mice (in vivo); Ginsenoside Rg1 promoted angiogenesis [48].
Effects of saponins (0.1–100 μg/mL) isolated from Panax notoginseng and Rg1(10 μg/mL) on angiogenesis in HUVECs (in vitro).; Total saponin and ginsenoside Rg1 promoted angiogenesis [49].
Effects of ginsenoside Rg3 (20 mg/kg, po) on angiogenesis and growth in lung carcinoma-implanted mice.; Ginsenoside Rg3 showed antiangiogenesis [50].