Table 1: Effects of various ginseng saponins on angiogenesis.

Effects of ginsenoside Rb2 (100 μg/mouse, iv) on tumor-induced angiogenesis in B16-BL6 melanoma-inoculated mice (in vivo)
 Ginsenoside Rb2 showed antiangiogenesis [25].

Effects of ginsenoside Rb2 (100 μg/mouse, iv and 300 μg/mouse, po), 20(R)Rg3 (100 μg/mouse, iv and 300 μg/mouse, po), and 20(S)Rg3 (100 μg/mouse, iv and 300 μg/mouse, po) on tumor-induced angiogenesis in B16-BL6 melanoma-inoculated mice (in vivo).
 Ginsenoside Rb2, 20(R)Rg3 and 20(S)Rg3, showed antiangiogenesis [40].

Effects of the total saponin fraction (10–100 μg/mL) on tube formation by HUVECs (in vitro).
 The total saponin fraction enhanced angiogenesis [22].

Effects of ginsenoside Rg1 (10 μM) and Rb1 (10 μM) on angiogenesis in scaffold implants in mice (in vivo).
Effects of Rg1 (125 nM) and Rb1 (125 nM) on chemoinvasion in HUVEC (in vitro).
 Ginsenoside Rg1 enhanced angiogenesis, and ginsenoside Rb1 showed antiangiogenesis in the earliest stage [23].

Effects of ginsenoside Re (10–100 μg/mL) on angiogenesis in HUVECs (in vitro).
Effects of Re (70 μg/extracellular matrix) on angiogenesis in extracellular matrix-implanted rats (in vivo).
 Ginsenoside Re showed angiogenesis [41].

Effects of ginsenoside Rg1 (150–600 nM) on angiogenesis in HUVECs (in vitro).
Effects of Rg1 (600 nM/Matrigel) on angiogenesis in Matrigel-implanted mice (in vivo).
 Ginsenoside Rg1 promoted angiogenesis [42].

Effects of 20(R)-ginsenoside Rg3(1-1000 nM) on angiogenesis in HUVECs (in vivo).
 20(R)-ginsenoside Rg3 showed antiangiogenesis [43].

Effects of Ginsenoside Rg1 (150 nM) on angiogenesis in HUVECs (in vitro).
 Ginsenoside Rg1 promoted angiogenesis [44].

Effects of ginsenoside Rg1 (30 μg/mL) and Re (30 μg/mL) on angiogenesis in HUVECs (in vitro).
Effects of Rg1 (50 μg/mL) and Re (50 μg/mL) on angiogenesis in Matrigel-implated mice (in vivo).
 Ginsenoside Rg1 and Re promoted angiogenesis [45].

Effects of ginsenoside Rg3 (3 mg/kg, ip) on growth and angiogenesis of ovarian cancer (in vivo).
 Ginsenoside Rg3 showed antiangiogenesis [46].

Effects of ginsenoside Rb1 (250 nM) on angiogenesis in HUVECs (in vitro).
 Ginsenoside Rb1 showed antiangiogenesis [47].

Effects of ginsenoside Rg1 (500 μg/Matrigel) on angiogenesis in Matrigel-implanted mice (in vivo)
 Ginsenoside Rg1 promoted angiogenesis [48].

Effects of saponins (0.1–100 μg/mL) isolated from Panax notoginseng and Rg1(10 μg/mL) on angiogenesis in HUVECs (in vitro).
 Total saponin and ginsenoside Rg1 promoted angiogenesis [49].

Effects of ginsenoside Rg3 (20 mg/kg, po) on angiogenesis and growth in lung carcinoma-implanted mice.
 Ginsenoside Rg3 showed antiangiogenesis [50].