Effects of Ginsenoside 𝐑𝐛_𝟏 on Skin Changes

Table 2

Effects of ginsenoside Rb₁ on angiogenesis from the area surrounding burn wounds in mice [26].

Treatment	Blood vessel length (mm/field)	Blood vessel area (mm^2/field)
Untreated burn wounds (control)	75.6±24.9	10.5±3.8
+Ginsenoside Rb1
(100 fg/wound)	228.8±38.6 *	46.6±15.0 *
(10 pg/wound)	203.0±17.0 *	37.6±5.5 *
(1 ng/wound)	274.1±37.4 *	49.9±4.7 *
+bFGF	241.5±28.3 *	35.8±5.9 *

The burn wounds were created on the backs of male Balb/c mice (6 weeks old) under anesthesia with pentobarbital. A polyethylene filter pellet (about 8 mm in diameter, 3 mm thick) containing the indicated amount of basic fibroblast growth factor (bFGF) or ginsenoside Rb₁ was applied to the burn wound surface. On day 9, any angiogenesis in the site surrounding the burn wound was photographed using a stereoscopic microscope, and the area and length of blood vessels were measured using a Coordinating Area and Curvimeter Machine (X-PLAN 360 dII, Ushitaka, Tokyo, Japan).
Values are the mean ± SE for six mice. *Significantly different from untreated burn wounds (control), 𝑃<0.05.