What Sequences on High-Field MR Best Depict Temporal Resolution of Experimental ICH and Edema Formation in Mice?
Figure 4
T2-weighted RARE spin-echo images at 24 hours (a) show predominantly low-signal hematoma within the left caudate/putamen, consistent with deoxyhemoglobin and intracellular methemoglobin. At 72 hours (b), there is conversion to predominantly high-signal, consistent with extracellular methemoglobin. In the course of hematoma resorption, the core hyperintensity (c) subsequently transforms to a hypointense gliotic scar at 21 days (d). The cryostat section stained with Luxol Fast Blue and cresyl violet [×10] (e) also well delineates the gliotic scar.
