Ethanol Extract of Cordyceps militaris Grown on Germinated Soybeans Attenuates Dextran-Sodium-Sulfate- (DSS-) Induced Colitis by Suppressing the Expression of Matrix Metalloproteinases and Inflammatory Mediators

Table 1

Histological score of DSS-induced colitis in GSC-treated mice.

	Control	3% DSS	3% DSS + GSC
Loss of epithelium	0.67 ± 0.58	2.67 ± 0.58^a	0.67 ± 1.15^d
Loss of crypt	0.33 ± 0.58	2.67 ± 0.58^b	1.33 ± 1.53^c
Loss of goblet cells	0.00 ± 0.00	2.33 ± 0.58^b	0.67 ± 1.15^d
Infiltration of inflammatory cells	0.00 ± 0.00	3.00 ± 0.00^b	1.33 ± 0.58^d
Total	1.00 ± 1.16	10.67 ± 1.73^b	4.00 ± 4.41^e

Each value represents the mean ± S.E.M. of 𝑛 ≥ 15 animals.
^a𝑃 < 0.01, ^b𝑃 < 0.001 versus Control; ^c𝑃 < 0.05, ^d𝑃 < 0.01, and ^e𝑃 < 0.001 versus DSS.
DSS: dextran sulfate sodium; GSC: Cordyceps  militaris grown on germinated soybeans.
3% DSS and GSC extract (500 mg/kg).