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BioMed Research International
Volume 2013 (2013), Article ID 121054, 13 pages
Review Article

Children with Generalised Joint Hypermobility and Musculoskeletal Complaints: State of the Art on Diagnostics, Clinical Characteristics, and Treatment

1Education of Physiotherapy, Amsterdam University of Applied Sciences, Tafelbergweg 51, 1105 BD Amsterdam, The Netherlands
2Department of Rehabilitation, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
3Department of Rehabilitation Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
4Adelante School for Public Health and Primary Care, Maastricht University, The Netherlands
5Education for Pediatric Physical Therapy, Avans University of Applied Sciences, Breda, The Netherlands
6Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
7Research Unit for Musculoskeletal Function and Physiotherapy, Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense M, Denmark

Received 12 April 2013; Revised 13 June 2013; Accepted 4 July 2013

Academic Editor: Fausto Catena

Copyright © 2013 M. C. Scheper et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. To provide a state of the art on diagnostics, clinical characteristics, and treatment of paediatric generalised joint hypermobility (GJH) and joint hypermobility syndrome (JHS). Method. A narrative review was performed regarding diagnostics and clinical characteristics. Effectiveness of treatment was evaluated by systematic review. Searches of Medline and Central were performed and included nonsymptomatic and symptomatic forms of GJH (JHS, collagen diseases). Results. In the last decade, scientific research has accumulated on all domains of the ICF. GJH/JHS can be considered as a clinical entity, which can have serious effects during all stages of life. However research regarding the pathological mechanism has resulted in new potential opportunities for treatment. When regarding the effectiveness of current treatments, the search identified 1318 studies, from which three were included (JHS: , Osteogenesis Imperfecta: ). According to the best evidence synthesis, there was strong evidence that enhancing physical fitness is an effective treatment for children with JHS. However this was based on only two studies. Conclusion. Based on the sparsely available knowledge on intervention studies, future longitudinal studies should focus on the effect of physical activity, fitness, and joint stabilisation. In JHS and chronic pain, the effectiveness of a multidisciplinary approach should be investigated.