Children with Generalised Joint Hypermobility and Musculoskeletal Complaints: State of the Art on Diagnostics, Clinical Characteristics, and Treatment

Table 1

Best evidence synthesis.

Level of evidence
Strong evidence:	Provided by statistically significant findings in outcome measures in at least 2 high-quality RCTs with PEDro scores of at least 4 points
Moderate evidence:	Provided by statistically significant findings in outcome measures in at least one high-quality RCT and at least one low-quality RCT (3 points on PEDro or one high-quality CCT)
Limited evidence:	Provided by statistically significant findings in outcome measures in at least one high-quality RCT or at least 2 high-quality CCTs (in the absence of high-quality RCTs)
Indicative evidence:	Findings provided by statistically significant findings in outcome measures in one high-quality CCT or low-quality RCTs (in the absence of high-quality RCTs), or 2 nonexperimental studies of sufficient quality (in the absence of RCTs and CCTs)
No or insufficient evidence:	In the event that results of eligible studies do not meet the criteria of one of the previously stated levels of evidence, or in case of conflicting (statistically significant positive and statistically significant negative) results among RCTs and CCTs, or when no eligible studies are available, CCTs indicates controlled clinical trial.