Figure 3: Biochemical changes during EndMT program. The EndMT program causes decreased expression of endothelial markers VE-cadherin, CD31, cytokeratins, and type 4 collagen and a gain of mesenchymal markers FSP-1, αSMA, N-cadherin, vimentin, fibronectin, type I and type III collagen, and MMP-2 and MMP-9. FSP-1: fibroblast-specific protein-1; α-SMA: α-smooth muscle actin; and MMP: matrix metalloproteinase.