A Novel Bone Morphogenetic Protein 2 Mutant Mouse, nBmp2NLS^tm, Displays Impaired Intracellular Ca²⁺ Handling in Skeletal Muscle

Figure 5

Muscle function is altered innBmp2NLS^tmmice. (a) Muscle fatigue in both control andnBmp2NLS^tmGPS muscle complex was similar in response to 2 Hz twitch contractions for 10 minutes. (b) Muscle relaxation was significantly delayed in nBmp2NLS^tm muscle compared to WT control muscle beginning at 60 seconds and persisting throughout the 10 minutes in which these measurements were made. Data are presented as mean ± SEM and * denotes𝑃<0.05,𝑛=7per group. Only the first significant difference is marked, but all values from 60 seconds on were significantly different from control.

(a)

(b)