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BioMed Research International
Volume 2013 (2013), Article ID 125658, 11 pages
http://dx.doi.org/10.1155/2013/125658
Review Article

Two-Photon Photodynamic Therapy by Water-Soluble Self-Assembled Conjugated Porphyrins

1Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0101, Japan
2Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 4-3-11 Takeda, Kofu, Yamanashi 400-8511, Japan
3Institute of Advanced Energy, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan

Received 26 July 2012; Revised 19 September 2012; Accepted 24 September 2012

Academic Editor: Kristjan Plaetzer

Copyright © 2013 Kazuya Ogawa and Yoshiaki Kobuke. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Studies on two-photon absorption (2PA) photodynamic therapy (PDT) by using three water-soluble porphyrin self-assemblies consisting of ethynylene-linked conjugated bis (imidazolylporphyrin) are reviewed. 2PA cross-section values in water were obtained by an open aperture Z-scan measurement, and values were extremely large compared with those of monomeric porphyrins such as hematoporphyrin. These compounds were found to generate singlet oxygen efficiently upon one- as well as two-photon absorption as demonstrated by the time-resolved luminescence measurement at the characteristic band of singlet oxygen at 1270 nm and by using its scavenger. Photocytotoxicities for HeLa cancer cells were examined and found to be as high as those of hematoporphyrin, demonstrating that these compounds are potential candidates for 2PA-photodynamic therapy agents.