Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2013, Article ID 125980, 5 pages
http://dx.doi.org/10.1155/2013/125980
Research Article

Pharmacological Evaluation and Antifertility Activity of Jatropha gossypifolia in Rats

1Department of Pharmacognosy, College of Pharmacy, IPS Academy, AB Road, Indore, Madhya Pradesh 452012, India
2School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore, Madhya Pradesh 452012, India

Received 5 April 2013; Revised 13 September 2013; Accepted 18 September 2013

Academic Editor: Kazim Husain

Copyright © 2013 Sachin Jain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. Pharmacological and antifertility activity evaluation of Jatropha gossypifolia in rats. Methods. The antifertility activity of the extracts of Jatropha gossypifolia in rats was evaluated using two experimental animal models. Estrogenic activity was evaluated in immature female rats using ethinyl estradiol as standard. Anti-implantation and early abortifacient activity was performed in female Wistar rats by determining the number of implantations and implantation resorptions. Results. In estrogenic activity evaluations, the ethanolic and aqueous extracts offered significant estrogen-like activity at 400 mg kg−1 p.o. by increasing the uterine weight compared to vehicle control group. Ethanolic extract (400 mg kg−1, p.o.) treatment significantly decreased the number of implants and increased the number of resorptions compared to vehicle control group. Conclusion. The results of the present study provide the evidence of the anti-fertility activity of Jatropha gossypifolia as claimed in the traditional use. The results are consistent with the literature reports related to the antifertility effect of flower extracts of Jatropha gossypifolia.