Research Article

Angiopoietin-Like 3 Induces Podocyte F-Actin Rearrangement through Integrin /FAK/PI3K Pathway-Mediated Rac1 Activation

Figure 1

Angptl3-induced actin filament rearrangement in podocytes, characterized by lamellipodia formation. (a) F-actin in podocytes after treatment with Angptl3 (250 ng/mL) for 15 min, 30 min, and 60 min versus control. Scale bar, 20 μm. Arrows in the pictures show the lamellipodia formation. Arrowheads show cell spikes. Pictures are representative of all the results obtained in the different experimental conditions. (b) Comparison of podocyte lamellipodia formation between groups ( , control group versus Angptl3 treatment groups, ** ).