Review Article
Innate Immunity Modulation by the IL-33/ST2 System in Intestinal Mucosa
Table 1
Functions of intestinal innate immune cells, role in IBD, and response to IL-33 stimulation.
| Cell | Function | Role in IBD | IL-33 effect |
| Goblet cell | Secretion of mucin, TFF3 and RELM-β. | Aberrant accumulation of mucin. Low TFF3 secretion. | Mucosecretagogue activity. | Macrophage | Phagocytosis. Antigen presentation. Intestinal antigenic tolerance. | Loss of tolerance. Increased CD14 and NF-κB expression. | Secretion of TNF, IL-1β, CXCL1, and CCL3. | Basophil mast cell | Defense against parasites. Allergic response. | Controversial. | Increased expression of surface ST2. Th2 cytokine secretion. Synergistically increases the IgE-mediated degranulation. | Eosinophil | Defense against parasites. Allergic response. | Higher eosinophilic protein content in feces and intestinal fluid. | Production of superoxide, IL-3, IL-5, IL-8, and GM-CSF. | Dendritic cell | Antigen presentation. Phagocytosis. Macropinocytosis. | Accumulation in inflamed area. Increased expression of TLR2, TLR4, and CD40. | Increases expression of MCH-II, CD86, and IL-6. Th2 differentiation. |
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