Clinicopathological Impact of ABCC1/MRP1 and ABCC4/MRP4 in Epithelial Ovarian Carcinoma

Table 5

Multivariable analysis of the prognostic impact of clinical covariates and MRPs on progression free survival in high-grade EOC.

	𝑃^∗	HR	(95% CI)
Stage
III-IV versus I-II	<0.0001	10.5	3.56–30.8
Histotype
Serous versus; others	0.96	0.98	0.47–2.05
Surgical debulking
SOD versus OD	0.016	2.22	1.16–4.26
Age at diagnosis
>55 versus ≤55	0.07	0.57	0.3–1.3
MRP1 expression
Positive versus; negative	0.11	0.58	0.31–1.13
MRP4 expression
Positive versus; negative	0.045	2.05	1.01–4.11

∗P value determined using log rank test; HR: hazard ratio; CI: confidence interval; SOD: suboptimal debulking (residual disease >1 cm), OD: optimal debulking (residual disease not evident or <1 cm).