Research Article
The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population
Table 7
Cytokines alleles and genotypes frequencies in HPV patients and controls.
| | Cytokine alleles and genotypes | HPV patients
| Controls
| Cytokine alleles and genotypes | HPV patients
| Controls
|
| | TNF −308 | | | IL10 −1082 | | | | G | 139 (88.0) | 174 (86.1) | G | 50 (32.1) | 72 (36) | | A | 19 (12.0) | 28 (13.9) | A | 106 (68) | 128 (64) | | G/G | 62 (78.5) | 73 (72.3) | G/G | 9 (11.5) | 12 (12) | | G/A | 15 (19.0) | 28 (27.7) | G/A | 32 (41.0) | 48 (48) | | A/A | 2 (2.5) | 0 (0) | A/A | 37 (47.4) | 40 (40) |
| | INFG +874 | | | IL10 −819 | | | | T | 69 (44.2) | 88 (44.9) | C | 98 (62.8) | 129 (64.5) | | A | 87 (55.8) | 108 (55.1) | T | 58 (37.2) | 71 (35.5) | | T/T | 19 (24.4) | 19 (19.4) | C/C | 31 (39.8) | 42 (42) | | T/A | 31 (39.7) | 50 (51.0) | C/T | 36 (46.2) | 45 (45) | | A/A | 28 (35.9) | 29 (29.6) | T/T | 11 (14.1) | 13 (13) |
| | IL6 −174 | | | IL10 −592 | | | | G | 116 (73.4) | 132 (65.4) | C | 98 (62.8) | 129 (64.5) | | C | 42 (26.6) | 70 (34.7) | A | 58 (37.2) | 71 (35.5) | | G/G | 44 (55.7) | 45 (44.6) | C/C | 31 (39.8) | 42 (42) | | G/C | 28 (35.4) | 42 (41.6) | C/A | 36 (46.2) | 45 (45) | | C/C | 7 (8.9) | 14 (13.9) | A/A | 11 (14.1) | 13 (13) |
| | TGFB1 +869 | | | TGFB1 +915 | | | | T | 89 (56.3) | 108 (54) | G | 141 (89.2) | 190 (95) | | C | 69 (43.7) | 92 (46) | C | 17 (10.7) | 10 (5) | | T/T | 26 (32.9) | 25 (25) | G/G | 63 (79.8) | 90 (90) | | T/C | 37 (46.8) | 58 (58) | G/C | 15 (19.0) | 10 (10) | | C/C | 16 (20.3) | 17 (17) | C/C | 1 (1.3) | 0 (0) |
|
|
: number of observed alleles and genotypes; %: allele and genotype frequencies.
Difference was not observed between both groups ().
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