Clinical Study
S100A12 and hBD2 Correlate with the Composition of the Fecal Microflora in ELBW Infants and Expansion of E. coli Is Associated with NEC
Table 1
Epidemiological characteristics.
| | | Group with NEC stage ≥2 () | Control group without any GI problems () | P value |
| | Gestational age | 25.4 (24.2–27) | 25.3 (23.3–27) | ns | | Birth weight in g | 747 (650–890) | 751 (354–990) | ns | | Umbilical artery pH at birth | 7.34 (7.26–7.45) | 7.32 (7.23–7.45) | ns | | CrP at birth in mg/dL | 1.52 (0.3–4.32) | 1.67 (0.2–4.64) | ns | | Oral feeding day 7 in mL/kg | 92.4 (50–142) | 84.9 (50–168) | ns | | Parenteral fluids day 7 in mL/kg | 77.6 (21–140) | 78.8 (0–128) | ns | | Mean onset of NEC (postnatal day) | 14.8 (8–28) | — | — | | Female (N) | 50% (6) | 58.9% (33) | ns | | Delivery per caesarean section (N) | 91.6% (11) | 91.1% (51) | ns | | Antibiotic therapy at day 7 (N) | 83.3% (10) | 66% (37) | ns | | Exclusively breast fed at day 7 (N) | 16.7% (2) | 19.6% (11) | ns | | MEDIAN LOG10 CFU per mg at day 7 | | | | | Total Bacterial count | 8.5 (8.2–10.7) | 8.7 (7.8–9.1) | ns | | Lactobacilli | 8.1 (7.2–9.0) | 7.4 (6.9–8.2) | <0.01 | | C. difficile (if positive) | 7.5 (4.8–11.0) | 5.9 (5.2–9.6) | ns | | E. coli | 7.0 (6.0–7.6) | 7.5 (6.6–7.9) | <0.05 | | Bifidobacteria | 7.4 (6.1–7.7) | 7.6 (5.5–7.9) | ns | | B. fragilis group | 6.0 (5.2–6.6) | 6.0 (5.4–6.7) | ns | | Others | 7.7 (7.2–10.2) | 7.9 (6.8–10.9) | ns | | Prevalence of C. difficile at day 7 (N) | 33.3% (4) | 26.8% (15) | ns |
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