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BioMed Research International
Volume 2013, Article ID 151509, 9 pages
Review Article

Topical Promethazine Side Effects: Our Experience and Review of the Literature

1Department of Dermatology and Plastic Surgery, University “Sapienza” of Rome, Viale del Policlinico 155, 00161 Rome, Italy
2Section of Legal Medicine, Department of Anatomical, Histological, Medical Legal and Locomotive System Sciences, University of Rome “Sapienza”, Viale Regina Elena 336, 00161 Rome, Italy

Received 1 May 2013; Revised 19 August 2013; Accepted 24 September 2013

Academic Editor: Ronald E. Baynes

Copyright © 2013 C. Cantisani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Promethazine hydrochloride is a first-generation H1 receptor antagonist, antihistamine, and antiemetic medication that can also have strong sedative effects. The apparent ability of topical H1r/2r antagonists to target epidermal H1/2r was translated into increased efficacy in the treatment of inflammatory dermatoses, likely due to decreased inflammation and enhanced barrier function.