Human Mesenchymal Stem Cells Provide Protection against Radiation-Induced Liver Injury by Antioxidative Process, Vasculature Protection, Hepatocyte Differentiation, and Trophic Effects
Biochemical analyses of plasmatic urea, creatinine, transaminases, and MDA. 200 μL of plasma was collected from NOD/SCID mice subjected to TBI at 3.2 Gy and injected with hMSCs intravenously. Abbreviations: ALT: serum alanine aminotransferase; AST: serum aspartate aminotransferase. (a) Blood urea concentrations. ((b) and (c)) Blood AST and ALT concentrations, respectively. (d) Lipid peroxidation was assayed by measuring the amount of thiobarbituric acid (TBARS) formation. Irradiation induced oxidative stress (white histogram) and hMSC injection (gray histogram) decreased oxidative stress. All values are expressed as the mean and the standard error of the mean (SEM). The significance for all analyses was set at (**) and (***) and nonsignificance was noted as ns. Each group consisted of 5 animals ().
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