The Effect of Msh2 Knockdown on Toxicity Induced by tert-Butyl-hydroperoxide, Potassium Bromate, and Hydrogen Peroxide in Base Excision Repair Proficient and Deficient Cells

Table 1

Changes in resistance^a to t-BOOH and KBrO₃ in cell lines as a result of Msh2 knockdown in Nth1 ^+/+, Nth1 ^−/−, Mpg ^+/+, and Mpg ^−/− MEFs.

Cell line	% Msh2 gene; silencing	t-BOOH		KBrO3
		MTT	Clonogenic	MTT	Clonogenic
Nth1 ^+/+	88%	—	~↑^‡	—	—
Nth1 ^−/−	85%	↑***	—	↑***	↑*
Mpg ^+/+	85%	—	—	↑***	↑*
Mpg ^−/−	79%	↑***	—	↓ **	—

aAssessed by MTT and clonogenic assays.
^∗𝑃≤0.05; ^∗∗𝑃≤0.01; ^∗∗∗𝑃≤0.001; ^‡𝑃=0.06.