Research Article
Safety Evaluation of Turmeric Polysaccharide Extract: Assessment of Mutagenicity and Acute Oral Toxicity
Table 2
Mutagenicity testing of NR-INF-02 in Salmonella typhimurium TAMix strain.
| Treatment |
Concentration (µg/mL) | Number of revertants colonies |
S9 | Individual colony counts |
Mean ± S.D | Fold increase over baseline | R1 | R2 | R3 |
| NR-INF-02 |
15.87 | − | 0 | 2 | 0 | | 0.67 | + | 0 | 0 | 0 | | 0.00 |
50.14 | − | 0 | 0 | 1 | | 0.33 | + | 0 | 2 | 0 | | 0.37 |
158.46 | − | 0 | 0 | 2 | | 0.67 | + | 2 | 1 | 2 | | 0.92 |
500.72 | − | 0 | 1 | 0 | | 0.33 | + | 0 | 0 | 1 | | 0.18 |
1582.28 | − | 2 | 1 | 1 | | 1.33 | + | 0 | 2 | 0 | | 0.37 |
5000.00 | − | 0 | 3 | 2 | | 1.67 | + | 0 | 2 | 0 | | 0.37 | Vehicle control |
0 | − | 1 | 1 | 1 | | — | + | 0 | 0 | 2 | | — | Positive control 2-NF + 4-NQO | | − | 48 | 48 | 48 | | 48.00 | Positive control 2-AA | 5.00 | + | 45 | 41 | 47 | | 24.35 |
|
|
R: replicate; ; 2-NF: 2-nitrofluorene; 4-NQO: 4-nitroquinoline-N-oxide; 2-AA: 2-aminoanthracene.
|