Enhanced Topical Delivery of Tetrandrine by Ethosomes for Treatment of Arthritis

Table 2

The inhibition rate (%) of paw oedema in rats at different time for different tetrandrine formulations and market dexamethasone ointment (positive control).

Time	Ethosomes			Positive control	Liposomes	Solution
	High dose	Medium dose	Low dose
		Primary adjuvant arthritis
18 h	36.80	13.07	1.85	16.51	1.32	1.60
66 h	46.48	16.97	7.10	38.77	7.79	8.63
		Secondary adjuvant arthritis
10 d	66.01	34.62	44.72	79.07	43.31	30.70
13 d	62.64	35.37	44.00	78.81	42.76	14.96
15 d	67.60	40.36	41.90	78.99	42.29	14.59
18 d	70.95	46.33	41.13	82.72	53.98	42.66