In Silico Prediction and In Vitro Characterization of Multifunctional Human RNase3

Table 1

Specific functions of hRNaseA superfamily.

Function	RNase
	1	2	3	4	5	6	7	8
Protein identity	30%	67%	100%	28%	32%	43%	39%	39%
RNase activity	O	O	O	O	O	O	O	O
Cytotoxicity	O	O	O	O	O	ND	ND	ND
Heparin binding motif	X	O	O	X	O	O	O	X
Lipid binding activity	ND	O	O	ND	ND	ND	O	ND
Antimicrobial activity	ND	O	O	ND	O	ND	O	O
Inflammatory mediators	ND	O	O	ND	ND	ND	ND	ND
Reference	[29]	[30]	[31, 32]	[33, 34]	[35, 36]	[37]	[38, 39]	[40, 41]

Note: O, X, and ND, respectively, represent active, inactive, and not determined.