Research Article
Safety Assessment and Biological Effects of a New Cold Processed SilEmulsion for Dermatological Purpose
Table 5
Summary of the biological safety of the ingredients.
| INCI name | Acute toxicity | Dermal irritation | Ocular irritation | Sensitization | Genotoxicity/ carcinogenicity | References |
| Bis-PEG/PPG-16/16 PEG/PPG-16/16 dimethicone (and) caprylic/capric triglyceride | n.a | n.a | n.a | n.a | n.a | — |
| PEG-20 glyceryl laurate | Rat (oral) LD50 > 48 mL/kg |
Non irritant | Rabbit: non irritant | n.a | n.a | [15] |
| Isopropyl myristate | Rat (oral) LD50 > 5000 mg/kg | Rabbit (undiluted): mild irritant | Rabbit: minimally irritant | Guinea pig: nonsensitizer Human: nonsensitizer | n.a | [16, 17] |
| C12-15 alkyl benzoate | Rat (oral) LD50 > 2000 mg/kg Rabbit (dermal) LD50 > 2000 mg/kg | Rabbit: non irritant | Rabbit: non irritant | Guinea pig: non sensitizer | n.a | [18, 19]
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| Hidroxy propyl methyl cellulose | Oral LD50 > 10000 mg/kg | Can cause irritation | Can cause irritation | Guinea pig: non sensitizer | n.a | [12] |
| PVM/MA decadiene crosspolymer | Rat (oral) LD50 > 1500 mg/kg Rat (oral), 1% in solution LD50 > 5000 mg/kg | Rabbit: slightly irritant | May cause irritation | Human patch test: non sensitizer (2% gel) | In vitro gene mutation in bacteria: negative | [20] |
| Cetrimide | Rat (oral) LD50 > 400 < 600 mg/kg | Rabbit: irritant | Potent irritant | Sensitizer | Salmonella Typhimurium: negative | [21] |
| 1,5-Pentanediol | Rat (oral) LD50 10000 mg/kg Rabbit (dermal) LD50 > 19800 mg/kg | Rabbit: non irritant | Rabbit: non irritant | n.a | Ames test: negative | [22] |
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