Prostaglandin Analogous and Antioxidant Activity Mediated Gastroprotective Action of Tabernaemontana divaricata (L.) R. Br. Flower Methanolic Extract against Chemically Induced Gastric Ulcers in Rats

Table 1

Results of ethanol induced gastric ulcers model.

Parameters	Negative control	Standard; misoprostol; 100 μg/kg	Test-I; TDFME; 125 mg/kg	Test-II; TDFME; 250 mg/kg	Test-III; TDFME; 500 mg/kg
Catalase	2.89±0.11 (0.27)	4.09±0.18 (0.44)^b	3.86±0.12 (0.49)^a	3.94±0.20 (0.49)^a	4.23±0.38 (0.94)^b
Malondialdehyde	7.11±0.30 (0.74)	2.69±0.23 (0.57)^c	5.64±0.29 (0.73)^b	4.94±0.16 (0.40)^c	3.58±0.24 (0.60)^c
Mucin content	0.52±0.06 (0.15)	1.07±0.11 (0.27)^b	0.95±0.15 (0.37)^a	1.15±0.10 (0.24)^b	1.89±0.11 (0.29)^c
Nonprotein sulphhydryl concentration	2.31±0.18 (0.45)	4.55±0.17 (0.42)^c	3.00±0.19 (0.47)^b	3.07±0.09 (0.24)^b	4.98±0.00 (0.23)^c
Superoxide dismutase	2.75±0.35 (0.86)	5.99±0.31 (0.78)^c	2.44±0.30 (0.74)^ns	4.05±0.23 (0.57)^a	4.07±0.24 (0.59)^a
Total protein content	342.5±4.09 (10.03)	313.2±3.22 (7.91)^c	321.7±4.68 (11.47)^b	316.5±5.50 (13.49)^b	251.7±4.15 (10.17)^c
Ulcer index	10±0.28 (0.70)	4.50±0.42 (1.04)^c	7.08±0.58 (1.42)^c	4.00±0.36 (0.89)^c	1.50±0.46 (1.14)^c

Note: sample size (𝑛) = 6 rats per group. Data is expressed as Mean ± Standard Error of Mean and Standard Deviation in parenthesis. ^a𝑃<0.05, ^b𝑃<0.01, ^c𝑃<0.001 and ^nsnonsignificant versus negative control (on statistical analysis with ANOVA, followed by Dunnett’s multiple comparison post-hoc test).