Table 1: Characterization of the EAE animal model and clinical parameters in rats with EAE and after treatment with antagonists of glutamate receptors.

EAEAmantadineMemantineLY 367385MPEP

Animals with clinical sings (%)96.2100100100100
Animals with severe EAE (%)73.962.7*63.6*73.670.0
Lethality (%)8.808.3 00
Inductive phase (days)
Maximal CI (score)
Cumulative CI (score)
Duration of disease (days)
Number of animals16024242424

The values represent the means ± SD. * , significantly different when compared with rats with EAE.