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BioMed Research International
Volume 2013, Article ID 186098, 6 pages
http://dx.doi.org/10.1155/2013/186098
Research Article

Protective Effect of Thunbergia laurifolia (Linn.) on Lead Induced Acetylcholinesterase Dysfunction and Cognitive Impairment in Mice

1Biomedical Science, School of Allied Health Sciences and Public Health, Walailak University, Nakhon Si Thammarat 80160, Thailand
2School of Allied Health Sciences and Public Health, School of Allied Health Sciences and Public Health, Walailak University, Nakhon Si Thammarat 80160, Thailand

Received 24 September 2013; Accepted 2 December 2013

Academic Editor: Fridoon Jawad Ahmad

Copyright © 2013 Moe Pwint Phyu and Jitbanjong Tangpong. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Thunbergia laurifolia (linn., TL), a natural phenolic compound, has been reported to have many benefits and medicinal properties. The current study ascertains the total phenolic content present in TL aqueous leaf extract and also examines the antioxidant ability of the extract in preserving acetylcholinesterase (AChE) activity of mice exposed to lead in vivo and in vitro model. Mice were given lead acetate (Pb) in drinking water (1 g/L) together with TL 100 and 200 mg/kg/day. The result showed that Pb induced AChE dysfunction in both in vitro and in vivo studies. TL significantly prevented Pb induced neurotoxicity in a dose-dependent manner which was indicated by comparatively better performance of TL treated mice in Morris Water Maze Swimming Test and increased AChE activity in the tissue sample collected from the brains of these mice. TL also exhibited the greatest amount of phenolic content, which has a significant positive correlation with its antioxidant capacity ( ). Taken together, these data suggested that the total phenolic compounds in TL could exhibit antioxidant and in part neuroprotective properties. It may play a potential treatment strategy for Pb contamination.