Reconstruction and Analysis of Human Kidney-Specific Metabolic Network Based on Omics Data
Biological processes enrichment analysis for PDG in comparison of kidney-specific metabolic network to heart-specific metabolic network. (a) shows the cellular metabolic processes overrepresented by kidney-PDG compared to the model of heart; it indicates that the kidney metabolic genes are largely involved in various processes, like amine metabolic process, indolalkylamine biosynthetic process, and hormone biosynthetic process. (b) shows the cellular metabolic processes overrepresented by heart-PDG compared to the model of kidney, it indicates that the heart metabolic genes are largely involved in other cellular process, such as cofactor metabolic process, coenzyme metabolic process, and glutathione biosynthetic process. GO annotation was performed by using BINGO. The yellow to orange color of the circles represents enriched GO categories, and the darkness of color is proportional to the significance level; the size of circle is proportional to the number of gene cluster annotated to that node. Only categories with a low value (<0.01) were considered as enriched in the network. value is determined by Hypergeometric statistical test employing the Benjamini and Hochberg false discovery rate correction.
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