Reconstruction and Analysis of Human Kidney-Specific Metabolic Network Based on Omics Data

Table 1

Top fifteen overrepresented metabolic processes of kidney-PDG compared with heart.

GO-ID	𝑃 value	Gene-num	Description
55114	1.78𝐸−15	20	Oxidation reduction
44281	2.92𝐸−12	23	Small molecule metabolic process
6725	2.33𝐸−11	10	Cellular aromatic compound metabolic process
6082	1.37𝐸−10	15	Organic acid metabolic process
8152	2.37𝐸−10	40	Metabolic process
44237	2.95𝐸−10	37	Cellular metabolic process
46219	4.67𝐸−10	4	Indolalkylamine biosynthetic process
42435	4.67𝐸−10	4	Indole derivative biosynthetic process
19752	1.37𝐸−09	14	Carboxylic acid metabolic process
43436	1.37𝐸−09	14	Oxoacid metabolic process
42180	1.88𝐸−09	14	Cellular ketone metabolic process
44106	2.72𝐸−09	11	Cellular amine metabolic process
9308	4.10𝐸−09	12	Amine metabolic process
46483	6.73𝐸−09	11	Heterocycle metabolic process
9309	9.80𝐸−09	7	Amine biosynthetic process

Note. This table lists the top fifteen overrepresented metabolic processes (𝑃 value < 0.01) in the kidney when compared with heart. This analysis was obtained from BINGO. GO categories were considered as enriched in the network as determined using Hypergeometric statistical test employing the Benjamini and Hochberg false discovery rate correction. The first column is the GO-ID. The second column is the 𝑃 value. The third column gives the number of the gene cluster, and the fourth column shows the description of the corresponding GO-ID.