The Impact of Hepatic Steatosis on Hepatic Ischemia-Reperfusion Injury in Experimental Studies: A Systematic Review

Table 7

Histological finding in experimental models of isolated perfused model and hepatic steatosis.

Author	Animal	Steatosis model	% steatosis	Type of steatosis	Duration of ischemia (mins)	Perfusate	Duration of reperfusion (mins)	Outcome measures	Effect of hepatic steatosis
von Heesen et al. [54]	Rat	FFD-C	40–50	MaS	24 hours	HTK	60	Histo	↑ Necrosis
Baskin-Bey et al. [55]	Mouse	CMDD	>40	MaS	24 hours	UW	60	Histo	↑ Liver injury
Arnault et al. [56]	Rat	HFD	80–100	MiS	12, 18, or 24 hours	UW	180	Histo	↑ Haemorrhage^1

CMDD: choline-methionine-deficient diet; HFD: high-fat diet; FFD-C: fat-free diet enriched with carbohydrate; Histo: histology; HTK: histidine-tryptophan-ketoglutarate solution; MaS: macrovesicular steatosis; MiS: microvesicular steatosis; UW: University of Wisconsin solution.
1Only in livers preserved for 24 hours.