The Pyridoxal 5′-Phosphate (PLP)-Dependent Enzyme Serine Palmitoyltransferase (SPT): Effects of the Small Subunits and Insights from Bacterial Mimics of Human hLCB2a HSAN1 Mutations
Figure 5
Structural models of the HSAN1 mutant mimic Sp SPT G268V using the Sp SPT PLP-L-serine external aldimine structure (PDB:2W8J). (a) Wild-type Sp SPT highlighting interactions within 5 Å of G268. (b) Mutated residue Val 268 showing new interactions within 5 Å. The models and figures were generated using PyMol software.
