Demethylation of Cancer/Testis Antigens and CpG ODN Stimulation Enhance Dendritic Cell and Cytotoxic T Lymphocyte Function in a Mouse Mammary Model
Granzyme B and perforin release from CTLs cocultured with DCs treated using different protocols (IL-2, P1A-specific peptide, CpG ODN, or P1A-specific peptide + CpG ODN). Both granzyme B and perforin secretion were markedly increased upon treatment with P1A-specific + CpG ODN (). Values are the means ± SD () of three individual experiments. and versus control; and versus group treated with P1A-specific peptide or CpG ODN.
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