Demethylation of Cancer/Testis Antigens and CpG ODN Stimulation Enhance Dendritic Cell and Cytotoxic T Lymphocyte Function in a Mouse Mammary Model
Antitumor Effect of H-2Ld-restricted P1A-specific CTLs in vivo. We established an mouse model bearing 4T1 cells. (a) H-2Ld-restricted P1A-specific CTLs significantly inhibited 4T1 cell growth in BALB/C mice treated with P1A-specific peptide + CpG ODN. (b) Tumor weight in the P1A-specific peptide + CpG ODN treated group was significantly lower than that of the control groups. , versus Control; , versus group treated with P1A-specific peptide or CpG ODN.
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