Prediction of Clinically Relevant Safety Signals of Nephrotoxicity through Plasma Metabolite Profiling

Table 2

Sum of toxicity patterns matching cyclosporin A-induced metabolite changes.

Toxicity	Cyclosporin A, low dose	Cyclosporin A, high dose
Blood, anemia		1
Bone, osteoblast inhibitor		2
GI tract, duodenum, iron deficiency	1	1
Immune system, immunosuppression	1	1
Kidney, diuretic effect		1
Kidney, interstitial nephritis		1
Kidney, glomerular tubular defect		1
Liver, paracetamol-like toxicity	2	2
Nervous system, serotonin receptor antagonist		1
Spleen, methemoglobinaemia		3
Grand total	4	14

See the legend for Table 1.