Research Article
Prediction of Clinically Relevant Safety Signals of Nephrotoxicity through Plasma Metabolite Profiling
Table 2
Sum of toxicity patterns matching cyclosporin A-induced metabolite changes.
| Toxicity | Cyclosporin A, low dose | Cyclosporin A, high dose |
| Blood, anemia | | 1 | Bone, osteoblast inhibitor | | 2 | GI tract, duodenum, iron deficiency | 1 | 1 | Immune system, immunosuppression | 1 | 1 | Kidney, diuretic effect | | 1 | Kidney, interstitial nephritis | | 1 | Kidney, glomerular tubular defect | | 1 | Liver, paracetamol-like toxicity | 2 | 2 | Nervous system, serotonin receptor antagonist | | 1 | Spleen, methemoglobinaemia | | 3 |
| Grand total | 4 | 14 |
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See the legend for Table 1.
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