Prediction of Clinically Relevant Safety Signals of Nephrotoxicity through Plasma Metabolite Profiling

Table 3

Sum of toxicity patterns matching doxorubicin-induced metabolite changes.

Toxicity	Doxorubicin, low dose	Doxorubicin, high dose
Blood, anemia		2
Bone marrow, suppression	2	2
Hormones, antiandrogen		1
Systemic antiproliferative		1
Kidney, tubular toxicity	1
Liver toxicity		1
Liver, enzyme induction		2
Thyroid, indirect effects		1
Grand total	3	10

See the legend for Table 1.