Prediction of Clinically Relevant Safety Signals of Nephrotoxicity through Plasma Metabolite Profiling

Table 4

Sum of toxicity patterns matching captopril-induced metabolite changes.

Toxicity	Captopril, low dose	Captopril, high dose
Adrenals, steroid biosynthesis inhibition		1
Bone marrow, suppression	2
Kidney, glomerular tubular defect	1	3
Kidney, tubular toxicity	2
Liver, oxidative stress	3
Phthalate toxicity	1
Grand total	9	4

See the legend for Table 1.