Prediction of Clinically Relevant Safety Signals of Nephrotoxicity through Plasma Metabolite Profiling

Table 5

Sum of toxicity patterns matching lisinopril-induced metabolite changes.

Toxicity	Lisinopril, low dose	Lisinopril, high dose
Blood, platelet aggregation inhibition		1
Kidney, ACE-inhibitor-like	1	1
Kidney, diuretic effect		1
Reduced food consumption	1
Grand total	2	3

See the legend for Table 1.