Review Article
Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma
Table 1
Human integrin subunits and their ligands.
| Integrin | Ligand | Type of receptors |
| α5β1 | Fibronectin | RGD receptors | α8β1 | Fibronectin/vitronectin/nephronectin | αvβ1 | Fibronectin/vitronectin | αvβ3 | Vitronectin/fibronectin/fibrinogen | αvβ5 | Vitronectin | αvβ6 | Fibronectin | αvβ8 | Vitronectin | αIIbβ3 | Fibrinogen/fibronectin |
| α1β1 | Collagen I/collagen IV/collagen IX | Collagen receptor | α2β1 | Collagen I/collagen IV/collagen IX | α10β1 | Collagen II/collagen IV/collagen VI/collagen IX | α11β1 | Collagen I/collagen IV/collagen IX |
| α3β1 | Laminin-511/laminin-332/laminin-211 | Laminin receptor | α6β1 | Laminin-511/laminin-332/laminin-111/laminin-411 | α6β4 | Laminin-511/laminin-332 | α7β1 | Laminin-511/laminin-211/laminin-111/laminin-411 |
| α4β1 | Fibronectin/VCAM-1 | Leukocyte-specific receptors | α4β7 α9β1 | MadCAM-1/fibronectin/VCAM-1 tenascin-C/VEGF-C/VEGF-D | αDβ2 | ICAM-3/VCAM-1 | αLβ2 | ICAM-1/ICAM-2/ICAM-3/ICAM-5 | αMβ2 | iC3b/fibronectin + more | αXβ2 | iC3b/fibronectin + more | αEβ7 | E-cadherin |
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RGD: arginine-glycine-aspartate, MadCAM: mucosal addressin cell adhesion molecule, ICAM: intercellular adhesion molecule, VCAM: vascular celladhesion molecule, and VEGF: vascular endothelial growth factor.
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