Particular Mal de Meleda Phenotypes in Tunisia and Mutations Founder Effect in the Mediterranean Region

Table 2

Clinical characteristics of the Mal de Meleda patients.

Patient's characteristics	Patient in family MDM-12	Patient in family MDM-13	Patients in family MDM-14
			Patient 1	Patient 2
Age (years)	40	40	2	13
Age of onset	First months	First months	First months	First months
Sex	F	M	M	F
Diffuse hyperkeratosis	++	++	+	+
Characteristics of transgressiveness	+++	++	+	+
Elbows involvement	++	−	−	−
Knees involvement	++	−	−	−
Palmoplantar hyperhidrosis	++	+	−	−
Malodor pachyderma	+++	++	+	+
Nails involvement	+++	++	++	++
Perioral erythema	+++	+	−	−
Keratolytic pits	−	−	++	++
Melanoma symptoms	−	−	−	−