Plasma and Ocular Prednisolone Disposition after Oral Treatment in Cats

Table 2

Plasma and aqueous humor pharmacokinetic parameters for prednisolone after a single oral administration (10 mg) to cats.

Pharmacokinetic parameter	Plasma		Aqueous humor
	Mean	SE	Mean	SE
𝑇1/2abs (h)	0.37	0.07	0.55	0.09
𝐶 max (ng/mL)	300.8	67.3	100.9	25.5
𝑇 max (h)	1	0.25	2.25	0.31
MRT (h)	2.24	0.42	4.39	0.64
𝑇1/2el (h)	0.87	0.16	2.25	0.44
AUC (ng·h/mL)	553.3	120.0	378.8	64.9

𝑇_1/2abs: absorption half-life; 𝐶_max: maximum concentration; 𝑇_max: time to maximum concentration; MRT: mean residence time; 𝑇_1/2el: elimination half-life; SE: standard error; AUC: area under the concentration—time curve.