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BioMed Research International
Volume 2013, Article ID 215283, 13 pages
Research Article

PPAR Activation Induces M1 Macrophage Polarization via cPLA2-COX-2 Inhibition, Activating ROS Production against Leishmania mexicana

Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del IPN, Avenida Instituto Politécnico Nacional No. 2508, Colonia San Pedro Zacatenco, Delegación Gustavo A. Madero, 07360 México, DF, Mexico

Received 11 August 2012; Revised 6 December 2012; Accepted 11 December 2012

Academic Editor: Jorge Morales-Montor

Copyright © 2013 J. A. Díaz-Gandarilla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1. COX-2 mRNA expression post-infection; Supplementary Figure 2. Cytokines mRNA expression post-infection; Supplementary Figure 3. MR expression in L. mexicana infected macrophages; Supplementary Figure 4. Prostaglandin production by L. mexicana infected macrophages.

  1. Supplementary Material