Research Article
Potential Utility of Sodium Selenate as an Adjunct to Metformin in Treating Type II Diabetes Mellitus in Rats: A Perspective on Protein Tyrosine Phosphatase
Table 1
Effect of daily administration of metformin (250 mg/kg; p.o.) [DIR + Met], sodium selenate (1.89 mg/kg; i.p.) [DIR + Sel], and metformin (250 mg/kg; p.o.) plus sodium selenate (5 mg/kg; i.p.) [DIR + Met + Sel] on body weight and serum content of glucose, insulin, and HOMA-IR index using DIR rats.
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Values represent the mean of 8 rats ± SEM (one-way ANOVA followed by LSD test). , , and compared to the control group. compared to DIR group. , compared to DIR + Met group. compared to DIR + Sel group. *HOMA-IR = Fasting serum glucose (mmol/L) × Fasting serum insulin (mIU/L)/22.5. |