Potential Utility of Sodium Selenate as an Adjunct to Metformin in Treating Type II Diabetes Mellitus in Rats: A Perspective on Protein Tyrosine Phosphatase

Table 2

Effect of daily administration of metformin (250 mg/kg) [DIR + Met; p.o.], sodium selenate (1.89 mg/kg; i.p.) [DIR + Sel], and metformin (250 mg/kg; p.o.) plus sodium selenate (1.89 mg/kg; i.p.) [DIR + Met + Sel] on serum content of TC, TG, and FFA using DIR rats.

Groups	Parameter
	Serum content (mg/dL)
	TC	TG	FFA
Control	64.814 ± 1.445	61.892 ± 3.357	16.400 ± 0.224
DIR	107.056 ± 3.565^c	155.809 ± 2.236^c	29.143 ± 0.395^c
DIR + Met	66.089 ± 0.984^f	88.193 ± 3.837^cf	19.252 ± 0.161^cf
DIR + Sel	66.381 ± 0.761^f	76.821 ± 1.967^bf	18.137 ± 0.287^cf
DIR + Met + Sel	66.858 ± 1.066^f	75.423 ± 2.171^f	17.612 ± 0.377^bfi

Values represent the mean of 8 rats ± SEM (one-way ANOVA followed by LSD test).
^b𝑃<0.01, ^c𝑃<0.001 compared to the control group. ^f𝑃<0.001 compared to DIR group. ⁱ𝑃<0.001 compared to DIR + Met group.