Preparation of Biocompatible Carboxymethyl Chitosan Nanoparticles for Delivery of Antibiotic Drug

Table 1

Design scheme and response values.

Formulation code	𝑋1^a	𝑋2^b	𝑋3^c	LE% (𝑌)^d	EE% (𝑍)^e	OD^f
1	0.18	45.00	4.00	5.76	58.27	0.61
2	0.12	55.00	5.00	3.71	85.52	0.70
3	0.06	45.00	5.00	5.89	48.29	0.43
4	0.18	55.00	4.50	5.33	43.48	0.27
5	0.18	35.00	4.50	6.24	51.68	0.52
6	0.12	35.00	4.00	5.08	68.29	0.69
7	0.18	45.00	5.00	3.36	39.25	0
8	0.12	45.00	4.50	4.85	53.42	0.47
9	0.06	55.00	4.50	1.53	58.38	0.13
10	0.12	45.00	4.50	4.88	53.42	0.47
11	0.06	45.00	4.00	1.31	49.30	0
12	0.12	45.00	4.50	4.76	54.65	0.48
13	0.12	55.00	4.00	4.19	58.44	0.49
14	0.12	45.00	4.50	4.55	55.21	0.48
15	0.06	35.00	4.50	2.01	55.08	0.22
16	0.12	35.00	5.00	4.00	70.23	0.60
17	0.12	45.00	4.50	4.66	55.04	0.48

aDrug/carboxymethyl chitosan, weight/weight; ^breacting temperature, °C; ^cadded amount of AlCl₃; ^dloading efficiency; ^eencapsulation efficiency; ^fgeneral normalized value.