Preparation of Biocompatible Carboxymethyl Chitosan Nanoparticles for Delivery of Antibiotic Drug

Table 2

Analysis of variance in RSM.

Source	Sum of squares	df	Mean square	F value	P value; probe > F
Model	0.72	9	0.080	20.79	0.0003
𝑋1	0.048	1	0.048	12.45	0.0096
𝑋2	0.024	1	0.024	6.27	0.0408
𝑋3	4.500𝐸−004	1	4.500𝐸−004	0.12	0.7428
𝑋1𝑋2	6.400𝐸−003	1	6.400𝐸−003	1.66	0.2388
𝑋1𝑋3	0.27	1	0.27	70.05	<0.0001
𝑋2𝑋3	0.022	1	0.022	5.83	0.0465
𝑋1^2	0.32	1	0.32	82.79	<0.0001
𝑋2^2	0.030	1	0.030	7.79	0.0269
𝑋3^2	0.015	1	0.015	3.86	0.0901
Residual	0.027	7	3.860𝐸−003
Lack of fit	0.027	3	8.967𝐸−003	298.89	<0.0001
Pure error	1.200𝐸−004	4	3.000𝐸−005
Cor total	0.75	16

𝑃<0.001 is highly significant; 𝑃<0.05 is significant.